Fruit Acids do not Enhance Sodium Lauryl Sulphate-induced Cumulative Irritant Contact Dermatitis In vivo

Fruit acids do not enhance sodium lauryl sulphate-induced cumulative irritant contact dermatitis in vivo.

Combined exposure to different irritants in the workplace may lead to irritant contact dermatitis, which is the main type of occupational dermatitis among bakers and confectioners. Following previous work on "tandem irritation", a panel of healthy volunteers was exposed twice daily for 4 days to the organic fruit acids: citric, malic, and lactic acid, either alone or in tandem application with ...

Studies on human skin lymph containing Langerhans cells from sodium lauryl sulphate contact dermatitis.

Immunologic processes in diseased human skin have been extensively investigated, but little is known about the effect of skin diseases on human afferent skin lymph. Starting in the papillary dermis, the skin lymphatics drain the adjacent tissue in a one-way flow toward the regional lymph nodes. The composition of the afferent lymph, therefore, reflects the immunologic inflammatory processes in ...

Anti-irritant and anti-inflammatory effects of glycerol and xylitol in sodium lauryl sulfate-induced acute irritation Effects of polyols in irritant contact dermatitis

E Szél, H Polyánka, K Szabó, P Hartmann, D Degovics, B Balázs, IB Németh, C Korponyai, E Csányi, J Kaszaki, S Dikstein, K Nagy, L Kemény, G Erős Department of Dermatology and Allergology, University of Szeged MTA SZTE Dermatological Research Group Institute of Surgical Research, University of Szeged Department of Pharmaceutical Technology, University of Szeged Unit of Cell Pharmacology, Hebrew ...

Allergic and Irritant Contact Dermatitis

Cytokines and Chemokines in Irritant Contact Dermatitis

Irritant contact dermatitis is a result of activated innate immune response to various external stimuli and consists of complex interplay which involves skin barrier disruption, cellular changes, and release of proinflammatory mediators. In this review, we will focus on key cytokines and chemokines involved in the pathogenesis of irritant contact dermatitis and also contrast the differences bet...